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New muscular dystrophy drug target identified
Scientists at the University of Liverpool have discovered that muscle cells affected by muscular dystrophy contain high levels of an enzyme that impairs muscle repair. This finding provides a new target for potential drug treatments for the disease, which currently has no cure. Muscular dystrophy MD is an inherited genetic condition that gradually causes a weakening of muscles. Duchenne muscular dystrophy DMD is the most common, and one of the most severe ...
EurekAlert - Wed. Jun 1
Premature babies may grow up to have weaker bones
Among the many important processes that happen during a woman s last few weeks of pregnancy is the transfer of calcium to the growing foetus to boost bone development. But what happens if this transfer is interrupted when a baby is born prematurely The answer, it seems, is lower peak bone mass as an adult, compared to adults who were born full term. Adults who were born full term but were small for their gestational age also had lower bone mass. These find ...
EurekAlert - Tue. May 31
Cells engineered from muscular dystrophy patients offer clues to variations in...
Johns Hopkins researchers report they have inadvertently found a way to make human muscle cells bearing genetic mutations from people with Duchenne muscular dystrophy DMD . A report on the feat, published online in the journal Cell Reports on May 26, should shed light on how subtle genetic differences among DMD patients produce symptoms with a wide range of severity and disability. The cells, they say, could also be used to test new therapies. The serendip ...
EurekAlert - Thu. May 26
Couples study ties anger to heart problems, stonewalling to back pain
If you rage with frustration during a marital spat, watch your blood pressure. If you keep a stiff upper lip, watch your back. New research from the University of California, Berkeley, and Northwestern University, based on how couples behave during conflicts, suggests outbursts of anger predict cardiovascular problem. Conversely, shutting down emotionally or stonewalling during conflict raises the risk of musculoskeletal ailments such as a bad back or stif ...
EurekAlert - Tue. May 24
New research could personalize medicine for arthritis patients
Joint injury can lead to post-traumatic osteoarthritis PTOA . In fact, about half of all people who rupture the anterior cruciate ligament ACL in their knee will develop PTOA within 10-20 years of the injury. But the molecular and cellular mechanisms leading to cartilage degeneration or PTOA due to trauma are not well understood. Recently, a team of scientists from Lawrence Livermore National Laboratory LLNL , University of California, Davis, University of ...
EurekAlert - Fri. May 20
TXA administered intravenously and by injection reduces blood loss after knee ...
A new study appearing in the Journal of Bone and Joint Surgery found that administering tranexamic acid TXA both intravenously IV and injected at the surgical site intra-articular administration, or IA reduced blood loss by 37 percent, compared to IV alone, following total knee replacement TKR . Administering TXA through IV or IA has been shown to reduce blood loss in several studies however, researchers had yet to investigate the impact of combining the d ...
EurekAlert - Fri. May 20
Use of arthroscopic hip surgery way up, but patient selection important for go...
For patients with serious, ongoing hip pain, sometimes surgery is their best bet for relief. Given the choice between minimally invasive hip surgery and total hip replacement, most patients would choose the less invasive procedure, often done on an outpatient basis. But a study by researchers at Hospital for Special Surgery HSS in New York City finds that arthroscopic surgery may not be the best option, especially if a patient is over 60 or has arthritis. ...
EurekAlert - Thu. May 19
Survey: 71 percent of hip fracture patients not told they have osteoporosis
Great Neck, NY - More than 7 in 10 older adults who suffer hip fractures aren t told they have the bone-weakening disease osteoporosis - despite the fact that hip fractures nearly always signify the presence of this potentially debilitating condition, according to revealing new research by Northwell Health physicians. Geriatric fellow Mia Barnett, MD, led a telephone survey of 42 hip fracture patients ages 65 and older that showed a startling level of misi ...
EurekAlert - Thu. May 19
Holidays in the sun hold key to boosting vitamin D, study finds
Holidays abroad may hold the key to tackling Scotland s vitamin D deficiency, research suggests. People who take foreign breaks have higher levels of vitamin D in their blood, which has been linked to wide-ranging health benefits, a study has found. Farmers also have higher levels of the vitamin -- which is produced in the skin after exposure to sunlight -- according to the findings. Researchers at the University of Edinburgh surveyed the vitamin D levels ...
EurekAlert - Wed. May 18
Children with swollen, painful knees: Is it Lyme disease or septic arthritis?
Septic or infectious arthritis of the knee and Lyme disease have similar symptoms in children but require different immediate treatment to ensure optimal recovery. A new study in the May 4 issue of the Journal of Bone and Joint Surgery identifies four symptoms that are predictive of septic arthritis when the condition presents itself in a child s knee--an important distinction in areas where Lyme disease is prevalent. Septic arthritis is considered a medic ...
EurekAlert - Thu. May 12
Patients may not need to wait 2 weeks to shower following knee replacement sur...
MAYWOOD, IL - A Loyola Medicine study suggests it may not be necessary for knee replacement patients to wait up to two weeks after surgery before showering, as many surgeons now require. The study compared patients who were allowed to shower two days after surgery with patients who had to wait 10 to 14 days. Researchers performed bacterial culture swabs of skin next to incisions, and no differences were found between the early-shower and delayed-shower gro ...
EurekAlert - Thu. May 12
Risks of heart attack, stroke may outweigh benefits of calcium supplement
With the highest reported risk of hip fractures in the word, Norway has good reason to consider the benefits and risks of calcium supplements. The challenge is that too little calcium and vitamin D in your diet leads to an increased risk of osteoporosis and broken bones, which taking supplements has been shown to help prevent. However, some studies have also shown that taking supplemental calcium may also increase your risk of heart attack and stroke. We c ...
EurekAlert - Thu. May 12