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New gene therapy for pseudarthrosis trialed at Kazan University
A team headed by Professor Albert Rizvanov, director of the Gene and Cell Technologies Open Lab, created a gene therapy drug that encodes growth factors for the stimulation of blood vessel and bone formation. The combination was highly effective in a patient admitted to the Republican Clinical Hospital in Kazan, Russia. The treatment was approved by the ethical committee, supported by the Ministry of Healthcare of Tatarstan and published in BioNanoScience ...
EurekAlert - Fri. Dec 2
XROMM, an influential 3-D, X-ray technology for biomechanics, gains new capabi...
PROVIDENCE, R.I. [Brown University] -- It s right there in the word discovery -- the idea of removing whatever cover may obscure a particular phenomenon from observation. And that s exactly what Brown University s X-ray Reconstruction of Moving Morphology technology does to reveal the inner workings of people and animals. With two recent papers describing powerful new software and a way to track muscle contractions, XROMM can do even more than before. And ...
EurekAlert - Thu. Dec 1
NEOMED researchers identify link between brain and bone in Alzheimer's disease
ROOTSTOWN, OH--Researchers at NEOMED have just identified a major connection between areas of the brainstem - the ancient area that controls mood, sleep and metabolism - and detrimental changes to bone in a preclinical model of Alzheimer s disease AD . The study, titled Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer s Disease, is led by Christine Dengler-Crish, Ph.D., assistant ...
EurekAlert - Thu. Dec 1
Could ambulatory surgical centers help bend the cost curve in US health care?
ROSEMONT, Ill. December 1, 2016 --U.S. healthcare costs have more than tripled since the 1960s1. Nearly one of every five dollars of national expenses1,2 are spent on health care. The Patient Protection and Affordable Care Act ACA --signed into law in 2010--aims to decrease healthcare delivery costs, improve quality and value of care, and improve population health. New research, published in the Journal of the American Academy of Orthopaedic Surgeons JAAOS ...
EurekAlert - Thu. Dec 1
Hyperuricemia is associated with musculoskeletal pain
Episodes of diffuse musculo-skeletal pain appearing in and around a joint region without a clear diagnosis, etiology and therapy are still a major problem in general medical practice. Our cross-sectional study addresses the question of whether slightly elevated urate levels are associated with musculo-skeletal pain. While the usefulness of urate-lowering treatment in patients with clinical manifestations of hyperuricemia has been established, its use in as ...
EurekAlert - Mon. Nov 28
Fibroblasts could provide new target for treatment of rheumatoid arthritis
A study led by researchers at the University of Birmingham reveals the key role of different types of fibroblast cells in the development of rheumatoid arthritis RA , opening up a new avenue for research into treatment of the disease. Synovial Fibroblasts SFs are cells that make up part of the connective tissue, or synovium, around human joints. In RA patients, SF cells cause damage by invading and attacking the cartilage and bone around the joint. A team ...
EurekAlert - Wed. Nov 23
'Minimal' shoes may reduce running injuries
Runners who wear trainers with no cushioning and land on the ball of their foot rather than the heel put significantly less demand on their bodies, new research suggests. Researchers compared how quickly the force acts when runners feet hit the ground -- known as the loading rate -- which has been shown to influence running injury risk. The study of 29 runners found significantly lower loading rates for those who wore so-called minimal trainers and landed ...
EurekAlert - Mon. Nov 21
Exercise may not provide benefit over physical therapy after knee replacement
In a randomized trial of patients who underwent total knee replacement as a treatment for osteoarthritis, a group program of strengthening and aerobic exercises was not better at alleviating long-term knee pain or overcoming activity limitations compared with usual care, which included physical therapy. Although most patients experienced less knee pain and improved physical function after undergoing total knee replacement, marked deficits in physical perfo ...
EurekAlert - Mon. Nov 21
Opioids, NSAIDs no different overall for persistent pain after vehicle crashes
PROVIDENCE, R.I. [Brown University] -- Persistent pain is common among the nearly 4 million Americans who arrive each year at hospital emergency departments EDs after car crashes. A new study in the journal Pain that compared the two most common pain-relief drugs -- NSAIDs such as ibuprofen and opioids such as oxycodone -- found that the risk of reporting persistent pain six weeks after a crash was not statistically different among patients prescribed eith ...
EurekAlert - Mon. Nov 21
Protective molecule sidelined in models of ALS
Researchers at the Virginia Tech Carilion Research Institute have identified a naturally occurring molecule that has the potential for preserving sites of communication between nerves and muscles in amyotrophic lateral sclerosis ALS and over the course of aging -- as well as a molecule that interferes with this helpful process. The discovery in mice has implications for patients with ALS, also known as Lou Gehrig s disease. Publishing this week as an early ...
EurekAlert - Fri. Nov 18
Menopausal hormone therapy improves bone health
Washington, DC--Women who undergo hormone therapy for menopausal symptoms such as hot flashes can not only increase bone mass, but also can improve bone structure, according to a new study published in the Endocrine Society s Journal of Clinical Endocrinology Metabolism . Previous studies have revealed the positive impact of menopausal hormone therapy MHT on bone mineral density. The new study is the first to show MHT also can improve bone mass and structu ...
EurekAlert - Thu. Nov 17
Better cartilage map could help researchers improve engineered joint repair
Cartilage serves as a shock absorber for the human body, lubricating joints and helping them move smoothly. Its texture is softer than bone -- yet stiffer and stronger than muscle. When it is damaged, patients can experience osteoarthritis, disc herniation and other painful conditions. This week in ACS Central Science , researchers reveal that the structure of cartilage has a more complicated zonal organization than previously thought, insights that could ...
EurekAlert - Wed. Nov 16